Ever dream of traveling the world but on a budget. Whether you are as adventurous enough to travel across the states on motorcoach bus or only a few hours within your home, Greyhound offers it all. In most cases, it is cheaper than flying. On some pay in advance, fares can be as low as a few dollars, example starting at $2 from Dallas to San Antonio or $2 from San Jose to Los Angeles (you need to look around to catch these special fares). (2012)
For your destination, there are a number of schedules for you to pick and you can see all the stops/transfers and cities on your route. The bus runs 24 hours, even driving through the night. Sounds scary? Well, I am one who still has flying phobias and will probably never get used to flying. Some of the 24 hour stations I've been to are occupied by many people so I feel as safe as anywhere else.
The cons is that there might be rest stops/ transfers at odd hours of the night/ morning if you are on a long schedule.
The pros, I've had inexpensive vacations, without having to pay lodging! Just take an overnight trip and sleep on the bus. Schedule a return the next night and avoid the cost of lodging! On most of my trips, the bus is almost full of people so it's not an unsafe feeling of being alone.
Update- there is another bus line even more cost effective but with more limited schedules and locations and may not have the 24 hr full service stations with restrooms/food service- The MegaBus. They have stations in downtown Dallas and Houston and a few in CA, Atlanta, etc. If you are looking for cheap travels the Megabus may be of interest if you have one in your area.
